Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward

Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward

The regulatory mechanisms underlying the response to addictive drugs are complex, and increasing evidence indicates that there is a role for appetite-regulating pathways in substance abuse. Leptin, an important adipose hormone that regulates energy balance and appetite, exerts its physiological functions via leptin receptors. However, the role of leptin signaling in regulating the response to c...

Nuclear factor B signaling regulates neuronal morphology and cocaine reward

Scott J. Russo,1 Matthew B. Wilkinson,1* Michelle S. Mazei-Robison,1* David M. Dietz,1 Ian Maze,1 Vaishnav Krishnan,2 William Renthal,2 Ami Graham,2 Shari G. Birnbaum,2 Thomas A. Green,2 Bruce Robison,2 Alan Lesselyong,2 Linda I. Perrotti,2 Carlos A. Bolaños,2 Arvind Kumar,2 Michael S. Clark,3 John F. Neumaier,3 Rachael L. Neve,4 Asha L. Bhakar,5 Philip A. Barker,5 and Eric J. Nestler1 1Fishber...

Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward.

We report here that the Src family tyrosine kinase Lyn negatively regulates the release of dopamine (DA) in the mesolimbic system, as well as the rewarding properties of alcohol. Specifically, we show that RNA interference-mediated knockdown of Lyn expression results in an increase in KCl-induced DA release in DAergic-like SH-SY5Y cells, whereas overexpression of a constitutively active form of...

The GSK3 Signaling Pathway Is Activated by Cocaine and Is Critical for Cocaine Conditioned Reward in Mice

The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states of the two kinases. The anatomical specificity of the response was determined, as was the contributions of dopamine and NMDA receptors to the action...

TRAF5 Negatively Regulates TLR Signaling